Flu season strikes early and, in some places, hard

NEW YORK (AP) — From the Rocky Mountains to New England, hospitals are swamped with people with flu symptoms. Some medical centers are turning away visitors or making them wear face masks, and one Pennsylvania hospital set up a tent outside its ER to deal with the feverish patients.

Flu season in the U.S. has struck early and, in many places, hard.

While flu normally doesn't blanket the country until late January or February, it is already widespread in more than 40 states, with about 30 of them reporting some major hot spots. On Thursday, health officials blamed the flu for the deaths of 20 children so far.

Whether this will be considered a bad season by the time it has run its course in the spring remains to be seen.

"Those of us with gray hair have seen worse," said Dr. William Schaffner, a flu expert at Vanderbilt University in Nashville.

The evidence so far points to a moderate season, Schaffner and others say. It looks bad in part because last year was unusually mild and because the main strain of influenza circulating this year tends to make people sicker and really lay them low.

David Smythe of New York City saw it happen to his 50-year-old girlfriend, who has been knocked out for about two weeks. "She's been in bed. She can't even get up," he said.

Also, the flu's early arrival coincided with spikes in a variety of other viruses, including a childhood malady that mimics flu and a new norovirus that causes vomiting and diarrhea, or what is commonly known as "stomach flu." So what people are calling the flu may, in fact, be something else.

"There may be more of an overlap than we normally see," said Dr. Joseph Bresee, who tracks the flu for the Centers for Disease Control and Prevention.

Most people don't undergo lab tests to confirm flu, and the symptoms are so similar that it can be hard to distinguish flu from other viruses, or even a cold. Over the holidays, 250 people were sickened at a Mormon missionary training center in Utah, but the culprit turned out to be a norovirus, not the flu.

Flu is a major contributor, though, to what's going on.

"I'd say 75 percent," said Dr. Dan Surdam, head of the emergency department at Cheyenne Regional Medical Center, Wyoming's largest hospital. The 17-bed emergency room saw its busiest day ever last week, with 166 visitors.

The early onslaught has resulted in a spike in hospitalizations. To deal with the influx and protect other patients from getting sick, hospitals are restricting visits from children, requiring family members to wear masks and banning anyone with flu symptoms from maternity wards.

One hospital in Allentown, Pa., set up a tent this week for a steady stream of patients with flu symptoms. But so far "what we're seeing is a typical flu season," said Terry Burger, director of infection control and prevention for the hospital, Lehigh Valley Hospital-Cedar Crest.

On Wednesday, Boston declared a public health emergency, with the city's hospitals counting about 1,500 emergency room visits since December by people with flu-like symptoms.

All the flu activity has led some to question whether this year's flu shot is working. While health officials are still analyzing the vaccine, early indications are that it's about 60 percent effective, which is in line with what's been seen in other years.

The vaccine is reformulated each year, based on experts' best guess of which strains of the virus will predominate. This year's vaccine is well-matched to what's going around. The government estimates that between a third and half of Americans have gotten the vaccine.

In New York City, 57-year-old Judith Quinones skipped getting a flu shot this season and suffered her worst case of flu-like illness in years. She was laid up for nearly a month with fever and body aches. "I just couldn't function," she said.

But her daughter got the vaccine. "And she got sick twice," Quinones said.

Europe is also suffering an early flu season, though a milder strain predominates there. Flu reports are up, too, in China, Japan, the West Bank, the Gaza Strip, Algeria and the Republic of Congo. Britain has seen a surge in cases of norovirus.

On average, about 24,000 Americans die each flu season, according to the CDC. That's an estimate — the agency does not keep a running tally of adult flu deaths each year, only for children. Some state health departments do keep count, and they've reported dozens of flu deaths so far.

Flu usually peaks in midwinter. Symptoms can include fever, cough, runny nose, head and body aches and fatigue. Some people also suffer vomiting and diarrhea, and some develop pneumonia or other severe complications.

Most people with flu have a mild illness and can help themselves and protect others by staying home and resting. But people with severe symptoms should see a doctor. They may be given antiviral drugs or other medications to ease symptoms.

Flu vaccinations are recommended for everyone 6 months or older. Of the 20 children killed by the flu this season, only two were fully vaccinated.

___

AP Medical Writer Maria Cheng in London contributed to this report.

___

Online:

CDC flu: http://www.cdc.gov/flu/index.htm

Read More..

Warner wins legal victory for control of Superman

SAN FRANCISCO (AP) — Just in time for the summer release of a hoped-for blockbuster movie "Man of Steel," Warner Bros. won a second significant legal victory Thursday giving it complete commercial control of the lucrative Superman franchise.

A three-judge panel of the 9th U.S. Circuit of Appeals unanimously ruled that the heirs of Superman's co-creator Jerome Siegel must abide by a 2001 letter written by the family's attorney accepting Warner Bros.' offer for their 50 percent share of Superman. Though the five-page letter was never formalized into a contract, the appeals court said it was still binding.

"Statements from the attorneys for both parties establish that the parties had undertaken years of negotiations, that they had resolved the last outstanding point in the deal during a conversation on Oct. 15, 2001, and that the letter accurately reflected the material terms they had orally agreed to on that day," Judge Stephen Reinhardt wrote for the panel.

The ruling Thursday undoes a 2008 trial court decision ordering Warner Bros. to share an undetermined amount of money earned since 1999 with the heirs, and to give the family control of key components of the Superman story, including his costume. If that decision were to stand, the studio would have had to negotiate a new costly royalty agreement with the family.

"The court's decision paves the way for the Siegel finally to receive the compensation they negotiated for and which DC has been prepared to pay for over a decade," Warner Bros. said in a prepared statement, referring to its DC Comics division. "We are extremely pleased that Superman's adventures can continue to be enjoyed across all media platforms worldwide for generations to come."

The family's attorney, Marc Toberoff, didn't respond to a request for comment.

Toberoff said earlier that he would appeal another significant Warner Bros. victory won in October involving the family of Superman's other creator, Joseph Shuster, and their bid for half the commercial rights. Toberoff also represents the Shuster heirs, who lost their bid to retain a 50 percent share of Superman.

A federal judge in Los Angeles had ruled that Shuster's sister and brother relinquished any chance to reclaim Superman copyrights in exchange for annual pension payments from DC Comics. U.S. District Judge Otis Wright noted in that case that the families of both creators have been paid in excess of $4 million since 1978, plus undefined bonuses and medical benefits.

In April, the $412 check that DC Comics wrote in 1938 to acquire Superman and other creative works by Shuster and Siegel sold for $160,000 in an online auction.

Read More..

Boeing to cut 40% of jobs, space at Texas plant

Guest are reflected in a Dreamliner fuselage at the jet's debut July 8, 2007, at the Boeing plant in Everett, Wash. (Robert Sorbo/Reuters / January 10, 2013)

5:06 p.m. CST, January 10, 2013

Boeing Co. said it will cut a little more than 40 percent of jobs, or 160 positions, at its El Paso, Texas, plant in response to planned U.S. defense budget reductions.

The company said it will trim occupied square footage 50 percent at the plant by moving from three buildings to one. The plant in Texas manufactures electronics for a variety of Boeing products.

The cuts will be completed by the end of 2014, the company said.

Boeing announced a major restructuring of its defense division in November that would cut 30 percent of management jobs from 2010 levels, close facilities and consolidate several business units.

The company's shares closed at $77.09 on the New York Stock Exchange on Thursday.

Read More..

Bucks' strong second half enough for victory over Bulls

New coach Jim Boylan chuckled pregame Wednesday night when asked if he discussed what happened the last time the Bucks visited the United Center.

"I don't think you want to bring up the fact you were down 27 points midway through a third quarter," Boylan said.

This time, the Bucks "only" trailed by 15 in the opening period, but the comeback carried the same weight. Preventing the Bulls from posting their first, four-game winning streak this season, the Bucks stormed back behind a scintillating performance from Brandon Jennings for a 104-96 triumph.

Jennings scored 20 of his 35 points in the third period, mocking Nate Robinson's winged airplane routine on two of his four 3-pointers in the period.

"I don't know what set (Jennings) off," Boyland said. "It's two guys (him and Robinson) who like to talk a lot. Maybe that set him off."

That the Bucks rallied despite beating the Suns at home on Tuesday while the Bulls rested made the victory all the more impressive. Boylan is 2-0 since replacing the departed Scott Skiles on Monday.

Larry Sanders posted eight blocks as the Bulls shot 29.8 percent in the second half and the Bucks, who lead the league in this department, blocked 15 shots overall. Mike Dunleavy added 16 points and four 3-pointers off the bench as the Bucks displayed a solid team effort.

"Sanders' presence around the basket is intimidating," Boylan said. "Guys go in there and are looking for him.

The Bulls' last gasp faded when Marco Belinelli missed a wide-open 3-pointer with 69 seconds left and failed to close the 100-96 deficit. Belinelli later followed with a frustration foul on Sanders, who blocked his attempt on the next possession.

Carlos Boozer led the Bulls with his sixth straight double-double of 22 points and 11 rebounds.

Jennings' high-arcing teardrop jumper with 4 minutes, 59 seconds remaining continued his torrid night.

Typically, Kirk Hinrich guards Jennings, but he missed his fifth game this season with the right elbow injury suffered in Monday's victory over the Cavaliers.

"Having Kirk out was a huge factor because of the pressure he applies to Brandon in the backcourt, which is significant," Boylan said.

Thibodeau did his typical cat-and-mouse game regarding Hinrich's replacement, not telling stadium personnel Robinson was starting until 20 minutes before tipoff despite Boylan already announcing it. But Robinson announced his presence quickly, sinking his first three 3-pointers and scoring 13 points in the opening period.

That's when things were rolling for the Bulls. That didn't last.

"We gave Jennings space," Thibodeau said. "He's going to make shots. We started off the game and had a good edge. Then we started trading buckets and they picked up steam. They got to every loose ball, made all the effort plays. You usually get what you deserve. We got what we deserve.

"If you don't play with great intensity, particularly when you have people out, you're not going to give yourself a chance to win.

kcjohnson@tribune.com

Twitter @kcjhoop

Read More..

Lenovo entering 'PC plus' era, CEO says

LAS VEGAS (Reuters) - China's Lenovo Group Ltd, on track to become the world's No.1 personal computer maker, is leveraging on what it calls the "PC plus" era as the company ramps up its plant capacity in major markets including the United States.

PC demand growth has waned over the past year as more consumers flock to ultraportable and increasingly powerful tablets and smartphones for basic computing. Hewlett Packard (HP), Dell and other stalwarts of the PC industry are now fighting to sustain growth as tablet computers eat into their PC-related businesses.

But PCs aren't disappearing anytime soon.

"We don't live in a post-PC world," Lenovo Chief Executive Yuanqing Yang said in an interview in Las Vegas on Wednesday. "We are entering the PC plus era."

Yang said it is a post-PC world for one group: companies that do not innovate in PCs.

"In our industry many players think PCs have become a commodity product," he said. "We have never thought this way."

Lenovo, he said, has redefined the category with products like Yoga, a laptop running Microsoft Corp's Windows 8 that can be converted to a tablet PC by flipping the screen all the way backwards, and Twist, another laptop that has a screen connected through a hinge.

The two laptops have had brisk sales in the United States with Lenovo capturing 40 percent consumer market share in the $900 and above category.

MARKET SHARE

Lenovo vaulted into the PC market by buying IBM's personal computer division in 2005. It has become a force through aggressive pricing, overseas acquisitions and taking advantage of a fast-growing home market.

Lenovo is lagging HP in PC shipments in the third quarter by less than half a percentage point, according to IDC, a consultancy. IDC placed HP at the No.1 spot with a 15.9 percent market share, marginally ahead of Lenovo's 15.7 percent share.

But Gartner, a rival to IDC, said Lenovo held the lead, with a 15.7 percent market share in the third quarter of 2012 compared to HP's 15.5 percent.

A year earlier, HP held a 17 percent market share while Lenovo held 13.1 percent, Gartner said. In the third quarter of 2010, Lenovo ranked fourth with 10.4 percent, trailing HP with 17.5 percent, Acer with 13.1 percent, and Dell with 12.2 percent.

"Now we are nurturing new areas including smartphones and tablets," Yang said. "We have focused on this change for many years. We have prepared for this trend."

DIVERSE WORKFORCE

One of the secrets of Lenovo's success, apart from its strategy, is its diverse workforce, Yang said. Its nine-person executive team represents six countries, he said.

The company wants a manufacturing footprint to match, with plans to increase the number of plants in most of its major markets. It is building a plant in the U.S.

It also plans to add more local products and local research and development.

"We want to be a global-local company," Yang said.

Last year, Lenovo bought Brazilian electronics maker CCE, and U.S. cloud computing firm Stoneware.

Lenovo, which is making a concerted global push into tablets and ultrabooks, does not expect to launch a smartphone in the U.S. until it has more U.S. brand recognition, said Gerry Smith, head of North American business for Lenovo.

The lucrative U.S. phone market is dominated by Apple Inc and Google Inc gadgets.

Lenovo launched a number of smartphone models, including the S890 with a 5-inch screen, at the Consumer Electronics show, for distribution in various markets.

In its biggest market by revenue, China, it has 15 percent of smartphone sales, according to Gartner.

(Reporting by Poornima Gupta and Bill Rigby; Editing by Ryan Woo)

Read More..

Steroids fallout: No BB Hall for Bonds, Clemens

NEW YORK (AP) — No one was elected to the Hall of Fame this year. When voters closed the doors to Barry Bonds, Roger Clemens and Sammy Sosa, they also shut out everybody else.

For only the second time in four decades, baseball writers failed to give any player the 75 percent required for induction to Cooperstown, sending a powerful signal that stars of the Steroids Era will be held to a different standard.

All the awards and accomplishments collected over long careers by Bonds, Clemens and Sosa could not offset suspicions those feats were boosted by performance-enhancing drugs.

Voters also denied entry Wednesday to fellow newcomers Craig Biggio, Mike Piazza and Curt Schilling, along with holdovers Jack Morris, Jeff Bagwell and Lee Smith.

Among the most honored players of their generation, these standouts won't find their images among the 300 bronze plaques on the oak walls in Cooperstown, where — at least for now — the doors appear to be bolted shut on anyone tainted by PEDs.

"After what has been written and said over the last few years I'm not overly surprised," Clemens said in a statement he posted on Twitter.

Bonds, Clemens and Sosa retired after the 2007 season. They were eligible for the Hall for the first time and have up to 14 more years on the writers' ballot.

"Curt Schilling made a good point, everyone was guilty. Either you used PEDs, or you did nothing to stop their use," Hall of Famer Mike Schmidt said in an email to The Associated Press after this year's vote was announced. "This generation got rich. Seems there was a price to pay."

Biggio, 20th on the career list with 3,060 hits, appeared on 68.2 percent of the 569 ballots, the highest total but 39 votes shy. The three newcomers with the highest profiles failed to come close to even majority support, with Clemens at 37.6 percent, Bonds at 36.2 and Sosa at 12.5.

Other top vote-getters were Morris (67.7), Jeff Bagwell (59.6), Piazza (57.8), Tim Raines (52.2), Lee Smith (47.8) and Schilling (38.8).

"I'm kind of glad that nobody got in this year," Hall of Famer Al Kaline said. "I feel honored to be in the Hall of Fame. And I would've felt a little uneasy sitting up there on the stage, listening to some of these new guys talk about how great they were. ... I don't know how great some of these players up for election would've been without drugs. But to me, it's cheating."

At ceremonies in Cooperstown on July 28, the only inductees will be three men who died more than 70 years ago: Yankees owner Jacob Ruppert, umpire Hank O'Day and barehanded catcher Deacon White. They were chosen last month by the 16-member panel considering individuals from the era before integration in 1947.

"It is a dark day," said Jose Canseco, the former AL MVP who was among the first players to admit using steroids. "I think the players should organize some type of lawsuit against major league baseball or the writers. It's ridiculous. Most of these players really have no evidence against them. They've never tested positive or they've cleared themselves like Roger Clemens."

It was the eighth time the BBWAA failed to elect any players. There were four fewer votes than last year and five members submitted blank ballots.

"With 53 percent you can get to the White House, but you can't get to Cooperstown," BBWAA secretary-treasurer Jack O'Connell said. "It's the 75 percent that makes it difficult."

There have been calls for the voting to be taken away from the writers and be given to a more diverse electorate that would include players and broadcasters. The Hall says it is content with the process, which began in 1936.

"It takes time for history to sort itself out, and I'm not surprised we had a shutout today," Hall President Jeff Idelson said. "I wish we had an electee. I will say that, but I'm not surprised given how volatile this era has been in terms of assessing the qualities and the quantities of the statistics and the impact on the game these players have had."

Bonds, baseball's only seven-time Most Valuable Player, hit 762 home runs, including a record 73 in 2001. He was indicted on charges he lied to a grand jury in 2003 when he denied using PEDs but a jury two years ago failed to reach a verdict on three counts he made false statements and convicted him on one obstruction of justice count, finding he gave an evasive answer.

"It is unimaginable that the best player to ever play the game would not be a unanimous first-ballot selection," said Jeff Borris of the Beverly Hills Sports Council, Bonds' longtime agent.

Clemens, the only seven-time Cy Young Award winner, is third in career strikeouts (4,672) and ninth in wins (354). He was acquitted last year on one count of obstruction of Congress, three counts of making false statements to Congress and two counts of perjury, all stemming from his denials of drug use.

"To those who did take the time to look at the facts," Clemens said, "we very much appreciate it."

Sosa, eighth with 609 home runs, was among those who tested positive in MLB's 2003 anonymous survey, The New York Times reported in 2009. He told a congressional committee in 2005 that he never took illegal performance-enhancing drugs.

Since 1961, the only years the writers didn't elect a candidate had been when Yogi Berra topped the 1971 vote by appearing on 67 percent of the ballots cast and when Phil Niekro headed the 1996 ballot at 68 percent — both got in the following years. The other BBWAA elections without a winner were in 1945, 1946, 1950, 1958 and 1960.

Morris will make his final ballot appearance next year, when fellow pitchers Greg Maddux and Tom Glavine are eligible for the first time along with slugger Frank Thomas.

"Next year, I think you'll have a rather large class, and this year, for whatever reasons, you had a couple of guys come really close," Commissioner Bud Selig said at the owners' meetings in Paradise Valley, Ariz. "This is not to be voted to make sure that somebody gets in every year. It's to be voted on to make sure that they're deserving. I respect the writers as well as the Hall itself. This idea that this somehow diminishes the Hall of baseball is just ridiculous in my opinion."

Players' union head Michael Weiner called the vote "unfortunate, if not sad."

"To ignore the historic accomplishments of Barry Bonds and Roger Clemens, for example, is hard to justify. Moreover, to penalize players exonerated in legal proceedings — and others never even implicated — is simply unfair. The Hall of Fame is supposed to be for the best players to have ever played the game. Several such players were denied access to the Hall today. Hopefully this will be rectified by future voting."

The BBWAA election rules say "voting shall be based upon the player's record, playing ability, integrity, sportsmanship, character, and contributions to the team(s) on which the player played."

An Associated Press survey of 112 eligible voters conducted in late November after the ballot was announced indicated Bonds, Clemens and Sosa would fall well short of 50 percent. The big three drew even less support than that as the debate raged over who was Hall worthy.

Voters are writers who have been members of the BBWAA for 10 consecutive years at any point.

BBWAA president Susan Slusser of the San Francisco Chronicle said she didn't vote for Bonds, Clemens or Sosa.

"The evidence for steroid use is too strong," she said.

As for Biggio, "I'm surprised he didn't get in."

Mark McGwire, 10th on the career home run list with 583, received 16.9 percent on his seventh try, down from 19.5 last year. He got 23.7 percent in 2010 — a vote before he admitted using steroids and human growth hormone.

Rafael Palmeiro, among just four players with 500 homers and 3,000 hits along with Hank Aaron, Willie Mays and Eddie Murray, received 8.8 percent in his third try, down from 12.6 percent last year. Palmeiro received a 10-day suspension in 2005 for a positive test for performance-enhancing drugs, claiming it was due to a vitamin vial given to him by teammate Miguel Tejada.

MLB.com's Hal Bodley, the former baseball columnist for USA Today, said Biggio and others paid the price for other players using PEDs.

"They got caught in the undertow of the steroids thing," he said.

Bodley said this BBWAA vote was a "loud and clear" message on the steroids issue. He said he couldn't envision himself voting for stars linked to drugs.

"We've a forgiving society, I know that," he said. "But I have too great a passion for the sport."

NOTES: There were four write-in votes for career hits leader Pete Rose, who never appeared on the ballot because of his lifetime ban that followed an investigation of his gambling while manager of the Cincinnati Reds. ... Two-time NL MVP Dale Murphy received 18.6 percent in his 15th and final appearance. ... At the July 28 ceremonies, the Hall also will honor Lou Gehrig and Rogers Hornsby among a dozen players who never received formal inductions because of restrictions during World War II. ... Piazza has a book due out next month that could change the view of voters before the next election.

___

AP Sports Writers Dan Gelston, Mike Fitzpatrick, John Marshall and Ben Walker contributed to this report.

Read More..

“Les Miserables” soundtrack tops Billboard album chart

LOS ANGELES (Reuters) – The soundtrack to the big screen adaption of Broadway musical “Les Miserables” topped the Billboard 200 album chart on Wednesday, edging out British folk rockers Mumford & Sons.

“Les Miserables” sold 92,000 albums in the week, according to data from Nielsen SoundScan, a 32 percent decline from last week for the star-studded production featuring the singing of Russell Crowe, Anne Hathaway and Hugh Jackman. It was the No. 2 album last week.

The soundtrack had the poorest showing for a No. 1 album since Christian hip-hop and pop artist tobyMac’s “Eye on It” topped the chart in September with 69,000 in sales.

Mumford & Sons’ “Babel” rose to the second spot from No. 8, finishing behind “Les Mis” by only a thousand albums sold. The British band’s second album was boosted by a sale price and heavy promotion on the Apple iTunes Store.

Country-pop star Taylor Swift, whose album “Red” spent the past four weeks atop the chart, dropped to third.

“American Idol” winner Phillip Phillips’ “The World from the Side of the Moon” took fourth and British boy band One Direction’s “Take Me Home” was fifth on the chart.

U.S. album sales for last week, which totaled 6.26 million, rose 8 percent compared to the same week last year.

A total of 34.53 million songs were downloaded last week, a 5 percent increase from last year.

(Reporting by Eric Kelsey, editing by Jill Serjeant and Jackie Frank)

Music News Headlines – Yahoo! News

Title Post: “Les Miserables” soundtrack tops Billboard album chart
Url Post: http://www.news.fluser.com/les-miserables-soundtrack-tops-billboard-album-chart/
Link To Post : “Les Miserables” soundtrack tops Billboard album chart
Rating:
100%

based on 99998 ratings.
5 user reviews.
Author: Fluser SeoLink
Thanks for visiting the blog, If any criticism and suggestions please leave a comment

Read More..

Retooling Pap test to spot more kinds of cancer

WASHINGTON (AP) — For years, doctors have lamented that there's no Pap test for deadly ovarian cancer. Wednesday, scientists reported encouraging signs that one day, there might be.

Researchers are trying to retool the Pap, a test for cervical cancer that millions of women get, so that it could spot early signs of other gynecologic cancers, too.

How? It turns out that cells can flake off of tumors in the ovaries or the lining of the uterus, and float down to rest in the cervix, where Pap tests are performed. These cells are too rare to recognize under the microscope. But researchers from Johns Hopkins University used some sophisticated DNA testing on the Pap samples to uncover the evidence — gene mutations that show cancer is present.

In a pilot study, they analyzed Pap smears from 46 women who already were diagnosed with either ovarian or endometrial cancer. The new technique found all the endometrial cancers and 41 percent of the ovarian tumors, the team reported Wednesday in the journal Science Translational Medicine.

This is very early-stage research, and women shouldn't expect any change in their routine Paps. It will take years of additional testing to prove if the so-called PapGene technique really could work as a screening tool, used to spot cancer in women who thought they were healthy.

"Now the hard work begins," said Hopkins oncologist Dr. Luis Diaz, whose team is collecting hundreds of additional Pap samples for more study and is exploring ways to enhance the detection of ovarian cancer.

But if it ultimately pans out, "the neat part about this is, the patient won't feel anything different," and the Pap wouldn't be performed differently, Diaz added. The extra work would come in a lab.

The gene-based technique marks a new approach toward cancer screening, and specialists are watching closely.

"This is very encouraging, and it shows great potential," said American Cancer Society genetics expert Michael Melner.

"We are a long way from being able to see any impact on our patients," cautioned Dr. Shannon Westin of the University of Texas MD Anderson Cancer Center. She reviewed the research in an accompanying editorial, and said the ovarian cancer detection would need improvement if the test is to work.

But she noted that ovarian cancer has poor survival rates because it's rarely caught early. "If this screening test could identify ovarian cancer at an early stage, there would be a profound impact on patient outcomes and mortality," Westin said.

More than 22,000 U.S. women are diagnosed with ovarian cancer each year, and more than 15,000 die. Symptoms such as pain and bloating seldom are obvious until the cancer is more advanced, and numerous attempts at screening tests have failed.

Endometrial cancer affects about 47,000 women a year, and kills about 8,000. There is no screening test for it either, but most women are diagnosed early because of postmenopausal bleeding.

The Hopkins research piggybacks on one of the most successful cancer screening tools, the Pap, and a newer technology used along with it. With a standard Pap, a little brush scrapes off cells from the cervix, which are stored in a vial to examine for signs of cervical cancer. Today, many women's Paps undergo an additional DNA-based test to see if they harbor the HPV virus, which can spur cervical cancer.

So the Hopkins team, funded largely by cancer advocacy groups, decided to look for DNA evidence of other gynecologic tumors. It developed a method to rapidly screen the Pap samples for those mutations using standard genetics equipment that Diaz said wouldn't add much to the cost of a Pap-plus-HPV test. He said the technique could detect both early-stage and more advanced tumors. Importantly, tests of Paps from 14 healthy women turned up no false alarms.

The endometrial cancers may have been easier to find because cells from those tumors don't have as far to travel as ovarian cancer cells, Diaz said. Researchers will study whether inserting the Pap brush deeper, testing during different times of the menstrual cycle, or other factors might improve detection of ovarian cancer.

Read More..

Adele to make post-baby debut at Golden Globes

BEVERLY HILLS, Calif. (AP) — Adele is coming to the Golden Globes.

The executive producer of the show says the 24-year-old Grammy-winning pop star is set to make her first post-baby appearance at Sunday's ceremony, where she is nominated for original song for the James Bond theme "Skyfall."

Adele welcomed her first child, with boyfriend Simon Konecki, in October. The singer has kept a low profile since announcing her pregnancy in June after sweeping the Grammy Awards last February with six wins.

Her single, "Skyfall," will compete at the Golden Globes with Taylor Swift's song from "The Hunger Games," Jon Bon Jovi's number from "Stand Up Guys," Keith Urban's track from "Act of Valor," and "Suddenly" from "Les Miserables."

The Globes will be presented Sunday at the Beverly Hilton Hotel.

Read More..

Walgreen defends Express Scripts, Alliance Boots moves

Coming off a tumultuous year in which Walgreen lost millions of customers in a contract dispute with a pharmacy benefits manager, executives of the Deerfield-based pharmacy chain sought to reassure shareholders on Wednesday of better days ahead.

At its annual meeting at Navy Pier, Walgreen leaders told a lively crowd of about 2,000 that its new international footprint, a loyalty card and other initiatives, including an enhanced selection of fresh foods and a continued expansion of health care services, have positioned the company for long-term success.

Walgreen Chief Executive Greg Wasson defended its controversial decision a year ago to walk away from a contract with the pharmacy benefit manager Express Scripts Holding Co., whose customers accounted for nearly 11 percent of the total prescriptions Walgreen's filled in 2011. As a result, Walgreen hemorrhaged sales throughout much of the year and its share price tanked.

Shareholders peppered Wasson about the decision, which analysts and others have said could result in the permanent loss of some of its customers.

Nonetheless, Wasson said, "I believe we're a much stronger company today ... it was absolutely the right thing for our shareholders in the long term."

Wasson also faced heat for its decision last June to shell out $6.7 billion for a 45 percent stake in a European pharmacy chain.

Investors sent Walgreen shares down more than 9 percent after the announcement that it would acquire a portion of Alliance Boots GmbH, pushing its stock price below $29, a level not seen for nearly two years.

Michael Pryce-Jones, a senior governance researcher for CtW Investment Group, an activist group that works on behalf of union pension funds, said Walgreen entered into the deal at the wrong time and paid too much.

"The fact is, this is too big a bet going on in a very troubled part of the world," Pryce-Jones said of the deal.

Pryce-Jones implored Walgreen's board to consider bringing the measure to a vote at its 2014 annual meeting, a year before the company is expected to acquire the remaining 55 percent of Alliance Boots.

Walgreen Chief Financial Officer Wade Miquelon said the company conducted "a tremendous amount of due diligence" before agreeing to the pact, which he said remains a "compelling strategic opportunity."

pfrost@tribune.com | Twitter: @peterfrost

Read More..