Justin Bieber and Selena Gomez have broken up, reports say
















LOS ANGELES (Reuters) – Pop star Justin Bieber and his girlfriend, Selena Gomez, a Disney actress and singer, have broken up, ending a relationship that made them one of Hollywood’s most high-profile young couples, media reports said.


Bieber, 18, and Gomez, 20, disclosed their relationship in February 2011 when they appeared together at an Oscar night party after months of rumors of their dating.













E! Online late on Friday was the first to report the split, with other media outlets including US Weekly and People also saying the relationship was over. The reports cited unnamed sources close to the couple.


Representatives for Bieber and Gomez did not returns calls or emails on Saturday.


Bieber has released two No. 1 albums in just over a year – the holiday-themed “Under the Mistletoe” and his latest, “Believe.” In September, he topped Billboard’s “21 Under 21″ list of top young musical acts. It was his second year in a row with the title.


Gomez rose to fame as a teenager in the Walt Disney Co television series “Wizards of Waverly Place” and has enjoyed success as a pop singer.


(Reporting By Alex Dobuzinskis; Editing by Greg McCune and Peter Cooney)


Celebrity News Headlines – Yahoo! News



Read More..

Malaria vaccine a letdown for infants

LONDON (AP) — An experimental malaria vaccine once thought promising is turning out to be a disappointment, with a new study showing it is only about 30 percent effective at protecting infants from the killer disease.

That is a significant drop from a study last year done in slightly older children, which suggested the vaccine cut the malaria risk by about half — though that is still far below the protection provided from most vaccines. According to details released on Friday, the three-shot regimen reduced malaria cases by about 30 percent in infants aged 6 to 12 weeks, the target age for immunization.

Dr. Jennifer Cohn, a medical coordinator at Doctors Without Borders, described the vaccine's protection levels as "unacceptably low." She was not linked to the study.

Scientists have been working for decades to develop a malaria vaccine, a complicated endeavor since the disease is caused by five different species of parasites. There has never been an effective vaccine against a parasite. Worldwide, there are several dozen malaria vaccine candidates being researched.

In 2006, a group of experts led by the World Health Organization said a malaria vaccine should cut the risk of severe disease and death by at least half and should last longer than one year. Malaria is spread by mosquitoes and kills more than 650,000 people every year, mostly young children and pregnant women in Africa. Without a vaccine, officials have focused on distributing insecticide-treated bed nets, spraying homes with pesticides and ensuring access to good medicines.

In the new study, scientists found babies who got three doses of the vaccine had about 30 percent fewer cases of malaria than those who didn't get immunized. The research included more than 6,500 infants in Africa. Experts also found the vaccine reduced the amount of severe malaria by about 26 percent, up to 14 months after the babies were immunized.

Scientists said they needed to analyze the data further to understand why the vaccine may be working differently in different regions. For example, babies born in areas with high levels of malaria might inherit some antibodies from their mothers which could interfere with any vaccination.

"Maybe we should be thinking of a first-generation vaccine that is targeted only for certain children," said Dr. Salim Abdulla of the Ifakara Health Institute in Tanzania, one of the study investigators.

Results were presented at a conference in South Africa on Friday and released online by the New England Journal of Medicine. The study is scheduled to continue until 2014 and is being paid for by GlaxoSmithKline and the PATH Malaria Vaccine Initiative.

"The results look bad now, but they will probably be worse later," said Adrian Hill of Oxford University, who is developing a competing malaria vaccine. He noted the study showed the Glaxo vaccine lost its potency after several months. Hill said the vaccine might be a hard sell, compared to other vaccines like those for meningitis and pneumococcal disease — which are both effective and cheap.

"If it turns out to have a clear 30 percent efficacy, it is probably not worth it to implement this in Africa on a large scale," said Genton Blaise, a malaria expert at the Swiss Tropical and Public Health Institute in Basel, who also sits on a WHO advisory board.

Eleanor Riley of the London School of Hygiene and Tropical Medicine, said the vaccine might be useful if used together with other strategies, like bed nets. She was involved in an earlier study of the vaccine and had hoped for better results. "We're all a bit frustrated that it has proven so hard to make a malaria vaccine," she said. "The question is how much money are the funders willing to keep throwing at it."

Glaxo first developed the vaccine in 1987 and has invested $300 million in it so far.

WHO said it couldn't comment on the incomplete results and would wait until the trial was finished before drawing any conclusions.

Read More..

War photography exhibit debuts in Houston museum

HOUSTON (AP) — It was a moment Nina Berman did not expect to capture when she entered an Illinois wedding studio in 2006. She knew Tyler Ziegel had been horribly injured, his face mutilated beyond recognition by a suicide bombing in the Iraq War. She knew he was marrying his pretty high school sweetheart, perfect in a white, voluminous dress.

It was their expressions that were surprising.

"People don't think this war has any impact on Americans? Well here it is," Berman says of the image of a somber bride staring blankly, unsmiling at the camera, her war-ravaged groom alongside her, his head down.

"This was even more shocking because we're used to this kind of over-the-top joy that feels a little put on, and then you see this picture where they look like survivors of something really serious," Berman added.

The photograph that won a first place prize in the World Press Photos Award contest will stand out from other battlefield images in an exhibit "WAR/PHOTOGRAPHY: Images of Armed Conflict and Its Aftermath" that debuts Sunday — Veterans Day — in the Houston Museum of Fine Arts. From there, the exhibit will travel to The Annenberg Space for Photography in Los Angeles, the Corcoran Gallery of Art in Washington and The Brooklyn Museum in Brooklyn, N.Y.

The exhibit was painstakingly built by co-curators Anne Wilkes Tucker and Will Michels after the museum purchased a print of the famous picture of the raising of the flag at Iwo Jima, taken Feb. 23, 1945, by Associated Press photographer Joe Rosenthal. The curators decided the museum didn't have enough conflict photos, Tucker said, and in 2004, the pair began traveling around the country and the world in search of pictures.

Over nearly eight years and after viewing more than 1 million pictures, Tucker and Michels created an exhibit that includes 480 objects, including photo albums, original magazines and old cameras, by 280 photographers from 26 countries.

Some are well-known — such as the Rosenthal's picture and another AP photograph, of a naked girl running from a napalm attack during the Vietnam War taken in 1972 by Huynh Cong "Nick" Ut. Others, such as the Incinerated Iraqi, of a man's burned body seen through the shattered windshield of his car, will be new to most viewers.

"The point of all the photographs is that when a conflict occurs, it lingers," Tucker said.

The pictures hang on stark gray walls, and some are in small rooms with warning signs at the entrance designed to allow visitors to decide whether they want to view images that can be brutal in their honesty.

"It's something that we did to that man. Americans did it, we did it intentionally and it's a haunting picture," Michels said of the image of the burned Iraqi that hangs inside one of the rooms.

In some images, such as Don McCullin's picture of a U.S. Marine throwing a grenade at a North Vietnamese soldier in Hue, it is clear the photographer was in danger when immortalizing the moment. Looking at his image, McCullin recalled deciding to travel to Hue instead of Khe Sahn, as he had initially planned.

"It was the best decision I ever made," he said, smiling slightly as he looked at the picture, explaining that he took a risk by standing behind the Marine.

"This hand took a bullet, shattered it. It looked like a cauliflower," he said, pointing to the still-upraised hand that threw the grenade. "So the people he was trying to kill were trying to kill him."

McCullin, who worked at that time for The Sunday Times in London, has covered conflicts all over the world, from Lebanon and Israel to Biafra. Now 77, McCullin says he wonders, still, whether the hundreds of photos he's taken have been worthwhile. At times, he said, he lost faith in what he was doing because when one war ends, another begins.

Yet he believes journalists and photographers must never stop telling about the "waste of man in war."

"After seeing so much of it, I'm tired of thinking, 'Why aren't the people who rule our lives ... getting it?' " McCullin said, adding that he'd like to drag them all into the exhibit for an hour.

Berman didn't see the conflicts unfold. Instead, she waited for the wounded to come home, seeking to tell a story about war's aftermath.

Her project on the wounded developed in 2003. The Iraq War was at its height, and there was still no database, she said, to find names of wounded warriors returning home. So she scoured local newspapers on the Internet.

In 2004 she published a book called "Purple Hearts" that includes photographs taken over nine months of 20 different people. All were photographed at home, not in hospitals where, she said, "there's this expectation that this will all work out fine."

The curators, meanwhile, chose to tell the story objectively — refusing through the images they chose or the exhibit they prepared to take a pro- or anti-war stance, a decision that has invited criticism and sparked debate.

And maybe, that is the point.

___

Plushnick-Masti can be followed on Twitter at https://twitter.com/RamitMastiAP

Read More..

Walmart Black Friday 2012 coming even earlier









Cierra Hobson is a die-hard Black Friday shopper.

Every year she queues in front of one of her favorite stores, where she waits, in her pajamas, in hopes of bagging a good deal.

This year, Hobson and other deal-seekers will find some twists on the post-Thanksgiving Day ritual: coupons delivered via mobile phones and deeper discounts, maneuvers designed to make shopping easier for consumers and to set retailers on a strong start to the biggest shopping period of the year. But perhaps the biggest change will be an earlier start to the holiday rush.

Black Friday historically launched the day after Thanksgiving. But in recent years, stores have opened at 4 a.m., then midnight. Last year, retailers created a stir by opening at 10 p.m. Thursday. This year, Sears and Wal-Mart announced plans to open at 8 p.m.

"The name of the game this holiday season is who can do it best," said National Retail Federation spokeswoman Kathy Grannis.

"When (early openings) started in 2009, things were a little bit worse off in terms of consumer confidence," Grannis added. "At that point it was very necessary for retailers to get out there before anybody else, and that literally meant before midnight."

This year, holiday spending is expected to rise 4.1 percent, according to the retail federation. Last year, more than 24 percent of Black Friday shoppers were out before midnight and nearly 39 percent of shoppers were in the stores before 5 a.m.

Wal-Mart plans to greet shoppers with the likes of $89 Wii consoles and a $38 Blu-ray player. At Sears, there will be perks on sale items for members of its shopper loyalty program.

Both retailers are touting in-store pickup, allowing customers to buy items online and pick them up at the store, avoiding checkout lines.

The Disney Store plans to begin offering Black Friday deals on the Monday before Thanksgiving, though Disney stores will open at midnight in some markets and 5 a.m. in others. Ads leaked to Internet deal sites say Target stores will open at 9 p.m. on Thanksgiving.

Last year, Wal-Mart recorded its most customer traffic at 10 p.m. on Thanksgiving night, said spokesman Steven Restivo, adding that the retailer relied on focus groups, online surveys and other feedback to help it decide to open two hours earlier this year. "Our customers told us they loved our Thanksgiving event last year and wanted it again."

At Sears, staying open 26 consecutive hours through Black Friday gives its customers the flexibility they want and makes good business sense, said spokesman Brian Hanover.

"There's a segment of Sears customers who want that thrill of holiday shopping to start as soon as their Thanksgiving dinner ends," he said. "Traditionalists," he added, can wait for door busters at 4 a.m.

Despite discounts that often go beyond 50 percent, stores still make money on the sales, retail experts say. That's because shoppers in physical stores tend to spend more than they planned, said Sanjay Dhar, professor of marketing at the University of Chicago Booth School of Business.

In the store, "you end up making purchases that aren't as marked down, in addition to the door-buster deals," he said.

Opening earlier and staggering door-buster deals is not only a good way to make money, but it's also necessary for crowd control, retail watchers say. In 2008, a store employee was trampled to death in a Black Friday door-buster stampede at a Long Island, N.Y., Wal-Mart.

Hobson said she doesn't plan to start shopping Thanksgiving night, but she said she'll be up before dawn to catch sales at Express, a clothing store.

"Just knowing that everybody is doing the same thing I'm doing on the same day feels like the beginning of Christmas," she said.

Others worry that super-early openings could backfire.

Sheri Petras, CEO of CFI Group, a Michigan-based consultancy, said store employees grumpy from having to leave their Thanksgiving festivities will take out their anger on customers.

"Consumers will not spend as much with cranky employees," she said.

Some employees at Wal-Mart, Sears and Target say they'd like the day off.

Change.org, an activist website, said Friday that more than 20 new petitions were submitted by employees and consumers asking retailers to reconsider their Thanksgiving evening openings.

It's the second year the website has administered petitions calling for retailers to stick to traditional Black Friday openings.

In a statement distributed by OUR Walmart, a labor rights group, Wal-Mart employee Mary Pat Tifft, of Wisconsin, said she would be "devastated" if she had to work on Thanksgiving, because she is expecting her son home from Afghanistan for the holiday.

"This early opening is one more example of Walmart's disconnect with the workers who keep its stores running and disregard for all of our families. As the largest employer in the country, Walmart could be setting a standard for businesses to value families, but instead, this is one more Walmart policy that hurts the families of workers at its stores," she said.

crshropshire@tribune.com

Twitter @corilyns



Read More..

CIA Director David Petraeus quits post over affair












David Petraeus, the retired four-star general renowned for taking charge of the military campaigns in Iraq and then Afghanistan, abruptly resigned Friday as director of the CIA, admitting to an extramarital affair.

The affair was discovered during an FBI investigation, according to officials briefed on the developments. They spoke on condition of anonymity because they were not authorized to publicly discuss the matter.









Petraeus carried on the affair with his biographer and reserve Army officer Paula Broadwell, according to several U.S. officials with knowledge of the situation. They spoke anonymously because they were not authorized to discuss the investigation that led to the resignation publicly.

The FBI discovered the relationship by monitoring Petraeus' emails, after being alerted Broadwell may have had access to his personal email account, two of the officials said.

Broadwell did not respond to voice mail or email messages seeking comment.

Petraeus' resignation shocked Washington's intelligence and political communities. It was a sudden end to the public career of the best-known general of the post 9/11 wars, a man sometimes mentioned as a potential Republican presidential candidate. His service was effusively praised Friday in statements from lawmakers of both parties.

Petraeus, who turned 60 on Wednesday, told CIA employees in a statement that he had met with President Barack Obama at the White House on Thursday and asked to be allowed to resign. On Friday, the president accepted.

Petraeus told his staffers he was guilty of "extremely poor judgment" in the affair. "Such behavior is unacceptable, both as a husband and as the leader of an organization such as ours."

He has been married for 38 years to Holly Petraeus, whom he met when he was a cadet at the U.S. Military Academy at West Point, N.Y. She was the daughter of the academy superintendent. They have two children, and their son led an infantry platoon in Afghanistan.

Obama said in a statement that the retired general had provided "extraordinary service to the United States for decades" and had given a lifetime of service that "made our country safer and stronger." Obama called him "one of the outstanding general officers of his generation."

The president said that CIA Deputy Director Michael Morell would serve as acting director. Morell was the key CIA aide in the White House to President George W. Bush during the Sept. 11, 2001, terror attacks.

"I am completely confident that the CIA will continue to thrive and carry out its essential mission," Obama said.

Administration officials said the White House was first notified about the Petraeus affair on Wednesday, the day after the election. Obama, who returned to the White House that evening after spending Election Day in Chicago, wasn't informed until Thursday morning.

The Senate and House intelligence committees were briefed on Petraeus' resignation only after the news was reported in the media, said a congressional staffer, speaking anonymously because the staffer was not authorized to publicly discuss the sensitive briefings.

The resignation comes at a sensitive time. The administration and the CIA have struggled to defend security and intelligence lapses before the attack that killed the U.S. ambassador to Libya and three others. It was an issue during the presidential campaign that ended with Obama's re-election Tuesday.

The CIA has come under intense scrutiny for providing the White House and other administration officials with talking points that led them to say the Benghazi attack was a result of a film protest, not a militant terror attack. It has become clear that the CIA was aware the attack was distinct from the film protests roiling across other parts of the Muslim world.

Morell rather than Petraeus now is expected to testify at closed congressional briefings next week on the Sept. 11 attacks on the consulate in Benghazi.

For the director of the CIA, being engaged in an extramarital affair is considered a serious breach of security and a counterintelligence threat. If a foreign government had learned of the affair, the reasoning goes, Petraeus or Broadwell could have been blackmailed or otherwise compromised. Military justice considers conduct such as an extramarital affair to be possible grounds for court-martial.

Failure to resign also could create the perception for the rank and file that such behavior is acceptable.

Read More..

Exclusive: Google Ventures beefs up fund size to $300 million a year

SAN FRANCISCO (Reuters) - Google will increase the cash it allocates to its venture-capital arm to up to $300 million a year from $200 million, catapulting Google Ventures into the top echelon of corporate venture-capital funds.


Access to that sizeable checkbook means Google Ventures will be able to invest in more later-stage financing rounds, which tend to be in the tens of millions of dollars or more per investor.


It puts the firm on the same footing as more established corporate venture funds such as Intel's Intel Capital, which typically invests $300-$500 million a year.


"It puts a lot more wood behind the arrow if we need it," said Bill Maris, managing partner of Google Ventures.


Part of the rationale behind the increase is that Google Ventures is a relatively young firm, founded in 2009. Some of the companies it backed two or three years ago are now at later stages, potentially requiring larger cash infusions to grow further.


Google Ventures has taken an eclectic approach, investing in a broad spectrum of companies ranging from medicine to clean power to coupon companies.


Every year, it typically funds 40-50 "seed-stage" deals where it invests $250,000 or less in a company, and perhaps around 15 deals where it invests up to $10 million, Maris said. It aims to complete one or two deals annually in the $20-$50 million range, Maris said.


LACKING SUPERSTARS


Some of its investments include Nest, a smart-thermostat company; Foundation Medicine, which applies genomic analysis to cancer care; Relay Rides, a carsharing service; and smart-grid company Silver Spring Networks. Last year, its portfolio company HomeAway raised $216 million in an initial public offering.


Still, Google Ventures lacks superstar companies such as microblogging service Twitter or online bulletin-board company Pinterest. The firm's recent hiring of high-profile entrepreneur Kevin Rose as a partner could help attract higher-profile deals.


Soon it could have even more cash to play around with. "Larry has repeatedly asked me: 'What do you think you could do with a billion a year?'" said Maris, referring to Google chief executive Larry Page.


(Editing by Muralikumar Anantharaman)


Read More..

Beljan nearly passes out on his way to the lead

LAKE BUENA VISTA, Fla. (AP) — Charlie Beljan was worried about keeping his PGA Tour card when he showed up at Disney for the final tournament of the year. That changed Friday over five frightening hours when he felt a shortness of breath and his heart racing, and eventually told his caddie that he thought he was going to die.

His chest heaved. He called for paramedics at the turn and was told his blood pressure was not good. He sat in the middle of the fairway to rest and kneeled on the green to try to steady himself.

In one of the most remarkable rounds of the year, the 28-year-old rookie fought through it for an 8-under 64 to take a three-shot lead.

Moments after signing his card, Beljan was loaded onto a stretcher. His eyes were shut, his head tilted back — still wearing his visor — and his arms were folded across his stomach as paramedics loaded him into an ambulance parked beyond the 18th green at the Palm Course.

"I think he was scared," said his caddie, Rick Adcox. "He kept saying he thought he was going to die. He just had that feeling. I don't know why. But it was spooky."

A few hours later, his agent sent a text to PGA Tour officials from Celebration Hospital that Beljan was waiting on tests, feeling better and hopeful of being discharged from the hospital Friday evening. In a later text, agent Andy Dawson said even if Beljan remained in the hospital overnight, he still planned to play the third round.

Beljan was in the lead for the first time after any round going into the weekend at the Children's Miracle Network Hospitals Classic. It could not have come at a better time because he is No. 139 on the money list, and only the top 125 keep their full cards for next year.

The tour said Beljan complained of an elevated heart rate, shortness of breath and heart palpitations. Adcox said Beljan told him of numbness in his arms and he felt like he was going to faint.

"I thought they were going to stop him on 10 when they told him what the blood pressure was," he said. "He just said, 'I'm going to keep going until either I pass out or they take me off.' I kept saying, 'It doesn't matter to me. It's only a golf tournament. You've got many more.'"

The struggle was painfully clear the way Beljan constantly stooped over with his hands on his knees, backed off shots and tried to take deep breaths. That he wound up in the lead at 12-under 132 was simply amazing.

"It was bizarre," said Edward Loar, who played with Beljan. "I don't know if he thought he was going to make it. It sure didn't affect his golf. I heard him call for a paramedic on No. 9. Before the round, he said he was having a hard time breathing. Hopefully, the guy was all right. He was having a hard time breathing in there."

Beljan had a three-shot lead over seven players, including Henrik Stenson, Harris English, Charles Howell III and first-round leader Charlie Wi. He likely would need to finish in about 10th place to move into the top 125 and keep a job for next year — assuming he can even play.

Golf didn't seem to be a big priority across from the Magic Kingdom, and there were concerns Beljan would even finish his round.

"I thought a lot of times he was going to stop," Adcox said. "I didn't even think he was going to start. He asked me to go find a doctor at the beginning, and I did. The paramedics ... were on No. 10 waiting on him. Blood pressure wasn't good then. For him to go on, that was pretty much his decision.

When he did get over a shot, the outcome generally was superb.

"He hit four of the best iron shots I've seen on the par 5s," Loar said. "It was awesome to watch."

Adcox realized something wasn't right when Beljan called for a doctor on the practice range. He drilled his long second shot onto the green at the par-5 first hole, and when the caddie handed him a putter, he said Beljan told him, "I don't feel very good."

"He got up there and made the eagle and still said he didn't feel good," Adcox said. "It's been not good all day. The score was good."

The caddie said they didn't pay attention to the score Beljan was putting together, and because they were playing on the Palm Course that doesn't have many leaderboards, they didn't even know Beljan was in the lead until the round was over.

They simply started a countdown — one more hole, one more shot.

Beljan had two eagles and played the par 5s in 6 under. He struggled to finish, picking up a bogey on the 17th and missing the green to the right on the 18th. Facing a difficult chip, made even tougher that he looked wobbly over the ball, he hit a beautiful shot to 4 feet to save par.

The final two rounds move to the tougher Magnolia Course, which effectively feels like the final stage of Q-school for some of the players. Matt Jones and Mark Anderson, in that group at 9-under 135, can avoid going to the second stage of Q-school. Wi needs a win to have any hope of getting into the Masters. English is going for his first win.

Rod Pampling will have to sweat out his future at home in Dallas for the second straight year. He is No. 124 on the money list, made bogeys on the 16th and 17th holes and missed the cut by one shot. All that helps Pampling is that Billy Mayfair, who is No. 125 on the money list, also missed the cut, as did Gary Christian at No. 127.

Kevin Chappell was at No. 123, but he put together another solid round and suddenly is only four shots out of the lead. His card would appear to be safe.

Read More..

Philip Roth says he’s done writing
















NEW YORK (AP) — Exit, Philip Roth? Having conceived everything from turning into a breast to a polio epidemic in his native New Jersey, Roth has apparently given his imagination a rest.


The 79-year-old novelist recently told a French publication, Les inRocks, that his 2010 release “Nemesis” would be his last. Spokeswoman Lori Glazer of Houghton Mifflin Harcourt said Friday that she had spoken with Roth and that he confirmed his remarks. Roth’s literary agent, Andrew Wylie, declined comment.













Roth certainly produced, completing more than 20 novels over half a century and often turning out one a year. He won virtually every prize short of the Nobel and wrote such classics as “American Pastoral” and “Portnoy’s Complaint.”


His name will remain on new releases, if only because the Library of America has been issuing hardcover volumes of his work. Roth also is cooperating with award-winning biographer Blake Bailey on a book about his life.


The author chose an unexpected forum to break the news, but he has been hinting at his departure for years. He has said that he no longer reads fiction and seemed to say goodbye to his fictional alterego, Nathan Zuckerman, in the 2007 novel “Exit Ghost.”


Retirement is rarely the preferred option for writers, for whom the ability to tell stories or at least set down words is often synonymous with life itself. Poor health, discouragement and even madness are the more likely ways literary careers end. Roth apparently is fit and his recent novels had been received respectfully, if not with the awe of his most celebrated work.


“I don’t believe it,” Roth’s friend and fellow writer Cynthia Ozick said upon learning the news. “A writer who stops writing while still breathing has already declared herself posthumous.”


His parting words from “Nemesis”: “He seemed to us invincible.”


Roth’s interview appeared in French and has been translated, roughly, by The Associated Press. He tells Les inRocks that “Nemesis” was “mon dernier livre” (“My last book”) and refers to “Howard’s End” author E.M. Forster, and how he quit fiction in his 40s. Roth said he doesn’t plan to write a memoir, but will instead go through his archives and help ensure that Bailey’s biography comes out in his lifetime.


Explaining why he stopped, Roth said that at age 74 he became aware his time was limited and that he started re-reading his books of the past 20-30 years, in reverse order. He decided that he agreed with what the boxer Joe Louis had said late in life, that he had done the best he could with what he had.


Entertainment News Headlines – Yahoo! News



Read More..

Malaria vaccine a letdown for infants

LONDON (AP) — An experimental malaria vaccine once thought promising is turning out to be a disappointment, with a new study showing it is only about 30 percent effective at protecting infants from the killer disease.

That is a significant drop from a study last year done in slightly older children, which suggested the vaccine cut the malaria risk by about half — though that is still far below the protection provided from most vaccines. According to details released on Friday, the three-shot regimen reduced malaria cases by about 30 percent in infants aged 6 to 12 weeks, the target age for immunization.

Dr. Jennifer Cohn, a medical coordinator at Doctors Without Borders, described the vaccine's protection levels as "unacceptably low." She was not linked to the study.

Scientists have been working for decades to develop a malaria vaccine, a complicated endeavor since the disease is caused by five different species of parasites. There has never been an effective vaccine against a parasite. Worldwide, there are several dozen malaria vaccine candidates being researched.

In 2006, a group of experts led by the World Health Organization said a malaria vaccine should cut the risk of severe disease and death by at least half and should last longer than one year. Malaria is spread by mosquitoes and kills more than 650,000 people every year, mostly young children and pregnant women in Africa. Without a vaccine, officials have focused on distributing insecticide-treated bed nets, spraying homes with pesticides and ensuring access to good medicines.

In the new study, scientists found babies who got three doses of the vaccine had about 30 percent fewer cases of malaria than those who didn't get immunized. The research included more than 6,500 infants in Africa. Experts also found the vaccine reduced the amount of severe malaria by about 26 percent, up to 14 months after the babies were immunized.

Scientists said they needed to analyze the data further to understand why the vaccine may be working differently in different regions. For example, babies born in areas with high levels of malaria might inherit some antibodies from their mothers which could interfere with any vaccination.

"Maybe we should be thinking of a first-generation vaccine that is targeted only for certain children," said Dr. Salim Abdulla of the Ifakara Health Institute in Tanzania, one of the study investigators.

Results were presented at a conference in South Africa on Friday and released online by the New England Journal of Medicine. The study is scheduled to continue until 2014 and is being paid for by GlaxoSmithKline and the PATH Malaria Vaccine Initiative.

"The results look bad now, but they will probably be worse later," said Adrian Hill of Oxford University, who is developing a competing malaria vaccine. He noted the study showed the Glaxo vaccine lost its potency after several months. Hill said the vaccine might be a hard sell, compared to other vaccines like those for meningitis and pneumococcal disease — which are both effective and cheap.

"If it turns out to have a clear 30 percent efficacy, it is probably not worth it to implement this in Africa on a large scale," said Genton Blaise, a malaria expert at the Swiss Tropical and Public Health Institute in Basel, who also sits on a WHO advisory board.

Eleanor Riley of the London School of Hygiene and Tropical Medicine, said the vaccine might be useful if used together with other strategies, like bed nets. She was involved in an earlier study of the vaccine and had hoped for better results. "We're all a bit frustrated that it has proven so hard to make a malaria vaccine," she said. "The question is how much money are the funders willing to keep throwing at it."

Glaxo first developed the vaccine in 1987 and has invested $300 million in it so far.

WHO said it couldn't comment on the incomplete results and would wait until the trial was finished before drawing any conclusions.

Read More..

Rap -reality TV star to join Hawks broadcast

ATLANTA (AP) — T.I. added a new line to his expanding resume — broadcaster.

The Grammy Award-winning rapper and reality television joined the Atlanta Hawks' broadcast team Friday night as they hosted the NBA champion Miami Heat.

"This was a phenomenal opportunity," said T.I., whose actual name is Clifford Harris. "I really enjoyed myself. I look forward to the next time and doing an entire game."

After several bouts with the law, including a stint in federal prison on weapons charges, the Atlanta native has become active in the community and frequently attends Hawks' games. He sat at courtside between play-by-play man Bob Rathbun and analyst Duane Ferrell.

"They did all the heavy lifting," said the rapper, who was wearing several gold chains and an old-school Hawks cap. "I just chimed in here and there. I have a close relationship, both personally and professionally, with a lot of the guys out there."

Asked if he had any desire to buy a piece of the Hawks, following the path set by hip-hop star and Brooklyn Nets part-owner Jay-Z, T.I. just smiled.

"I would love to be a part of the organization in whatever way possible if I can make a significant contribution," he said. "But there's no pressure. Baby steps."

T.I. gave a hint of new album, "Trouble Man," which is scheduled for release on Dec. 18. It includes collaborations with Andre 3000, Cee Lo Green and Pink.

"I'm extremely proud of it," he said. "I put a lot of work and energy into it. I think it will be the classic album the fans have been wanting me to make. ... I wanted to mix it up. I wanted to raise the bar on what's considered stellar material."

He also stars with his wife in "T.I. and Tiny: The Family Hustle," a reality show on VH1. Camera crews from the show trailed him around Philips Arena.

T.I. is hopeful about the Hawks, who overhauled their roster during under offseason in hopes of breaking a history of postseason failures.

"This is a new team, a young team," he said. "They have a lot of heart, a lot of desire, a lot of talent that can take them deep in the playoffs."

As for his own athletic prowess, T.I. was frank about his abilities.

There was none of the boastfulness one might hear on his songs.

"I have no organized sports background," he said. "I've done a lot of watching. I'm a professional spectator. I can observe like no one's business."

___

Follow Paul Newberry on Twitter at www.twitter.com/pnewberry1963

Read More..